Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis.
Identifieur interne : 000016 ( PubMed/Checkpoint ); précédent : 000015; suivant : 000017Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis.
Auteurs : Imke Kirste [Allemagne] ; Zeina Nicola ; Golo Kronenberg ; Tara L. Walker ; Robert C. Liu ; Gerd KempermannSource :
- Brain structure & function ; 2015.
English descriptors
- KwdEn :
- Acoustic Stimulation (methods), Animals, Cell Proliferation, Evoked Potentials, Auditory, Brain Stem, Female, Hippocampus (cytology), Hippocampus (metabolism), Hippocampus (physiology), Mice, Inbred C57BL, Models, Animal, Music, Neural Stem Cells (metabolism), Neural Stem Cells (physiology), Neurogenesis, Neuronal Plasticity, Noise, SOXB1 Transcription Factors (metabolism), Time Factors, Vocalization, Animal.
- MESH :
- chemical , metabolism : SOXB1 Transcription Factors.
- cytology : Hippocampus.
- metabolism : Hippocampus, Neural Stem Cells.
- methods : Acoustic Stimulation.
- physiology : Hippocampus, Neural Stem Cells.
- Animals, Cell Proliferation, Evoked Potentials, Auditory, Brain Stem, Female, Mice, Inbred C57BL, Models, Animal, Music, Neurogenesis, Neuronal Plasticity, Noise, Time Factors, Vocalization, Animal.
Abstract
We have previously hypothesized that the reason why physical activity increases precursor cell proliferation in adult neurogenesis is that movement serves as non-specific signal to evoke the alertness required to meet cognitive demands. Thereby a pool of immature neurons is generated that are potentially recruitable by subsequent cognitive stimuli. Along these lines, we here tested whether auditory stimuli might exert a similar non-specific effect on adult neurogenesis in mice. We used the standard noise level in the animal facility as baseline and compared this condition to white noise, pup calls, and silence. In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448). All stimuli were transposed to the frequency range of C57BL/6 and hearing was objectified with acoustic evoked potentials. We found that except for white noise all stimuli, including silence, increased precursor cell proliferation (assessed 24 h after labeling with bromodeoxyuridine, BrdU). This could be explained by significant increases in BrdU-labeled Sox2-positive cells (type-1/2a). But after 7 days, only silence remained associated with increased numbers of BrdU-labeled cells. Compared to controls at this stage, exposure to silence had generated significantly increased numbers of BrdU/NeuN-labeled neurons. Our results indicate that the unnatural absence of auditory input as well as spectrotemporally rich albeit ethological irrelevant stimuli activate precursor cells-in the case of silence also leading to greater numbers of newborn immature neurons-whereas ambient and unstructured background auditory stimuli do not.
DOI: 10.1007/s00429-013-0679-3
PubMed: 24292324
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:24292324Le document en format XML
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Effects of auditory stimuli and their absence on adult hippocampal neurogenesis.</title><author><name sortKey="Kirste, Imke" sort="Kirste, Imke" uniqKey="Kirste I" first="Imke" last="Kirste">Imke Kirste</name><affiliation wicri:level="3"><nlm:affiliation>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Nicola, Zeina" sort="Nicola, Zeina" uniqKey="Nicola Z" first="Zeina" last="Nicola">Zeina Nicola</name></author><author><name sortKey="Kronenberg, Golo" sort="Kronenberg, Golo" uniqKey="Kronenberg G" first="Golo" last="Kronenberg">Golo Kronenberg</name></author><author><name sortKey="Walker, Tara L" sort="Walker, Tara L" uniqKey="Walker T" first="Tara L" last="Walker">Tara L. Walker</name></author><author><name sortKey="Liu, Robert C" sort="Liu, Robert C" uniqKey="Liu R" first="Robert C" last="Liu">Robert C. Liu</name></author><author><name sortKey="Kempermann, Gerd" sort="Kempermann, Gerd" uniqKey="Kempermann G" first="Gerd" last="Kempermann">Gerd Kempermann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1007/s00429-013-0679-3</idno><idno type="RBID">pubmed:24292324</idno><idno type="pmid">24292324</idno><idno type="wicri:Area/PubMed/Corpus">000043</idno><idno type="wicri:Area/PubMed/Curation">000043</idno><idno type="wicri:Area/PubMed/Checkpoint">000016</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis.</title><author><name sortKey="Kirste, Imke" sort="Kirste, Imke" uniqKey="Kirste I" first="Imke" last="Kirste">Imke Kirste</name><affiliation wicri:level="3"><nlm:affiliation>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Nicola, Zeina" sort="Nicola, Zeina" uniqKey="Nicola Z" first="Zeina" last="Nicola">Zeina Nicola</name></author><author><name sortKey="Kronenberg, Golo" sort="Kronenberg, Golo" uniqKey="Kronenberg G" first="Golo" last="Kronenberg">Golo Kronenberg</name></author><author><name sortKey="Walker, Tara L" sort="Walker, Tara L" uniqKey="Walker T" first="Tara L" last="Walker">Tara L. Walker</name></author><author><name sortKey="Liu, Robert C" sort="Liu, Robert C" uniqKey="Liu R" first="Robert C" last="Liu">Robert C. Liu</name></author><author><name sortKey="Kempermann, Gerd" sort="Kempermann, Gerd" uniqKey="Kempermann G" first="Gerd" last="Kempermann">Gerd Kempermann</name></author></analytic><series><title level="j">Brain structure & function</title><idno type="e-ISSN">1863-2661</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation (methods)</term><term>Animals</term><term>Cell Proliferation</term><term>Evoked Potentials, Auditory, Brain Stem</term><term>Female</term><term>Hippocampus (cytology)</term><term>Hippocampus (metabolism)</term><term>Hippocampus (physiology)</term><term>Mice, Inbred C57BL</term><term>Models, Animal</term><term>Music</term><term>Neural Stem Cells (metabolism)</term><term>Neural Stem Cells (physiology)</term><term>Neurogenesis</term><term>Neuronal Plasticity</term><term>Noise</term><term>SOXB1 Transcription Factors (metabolism)</term><term>Time Factors</term><term>Vocalization, Animal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>SOXB1 Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Hippocampus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Hippocampus</term><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Acoustic Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hippocampus</term><term>Neural Stem Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Evoked Potentials, Auditory, Brain Stem</term><term>Female</term><term>Mice, Inbred C57BL</term><term>Models, Animal</term><term>Music</term><term>Neurogenesis</term><term>Neuronal Plasticity</term><term>Noise</term><term>Time Factors</term><term>Vocalization, Animal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have previously hypothesized that the reason why physical activity increases precursor cell proliferation in adult neurogenesis is that movement serves as non-specific signal to evoke the alertness required to meet cognitive demands. Thereby a pool of immature neurons is generated that are potentially recruitable by subsequent cognitive stimuli. Along these lines, we here tested whether auditory stimuli might exert a similar non-specific effect on adult neurogenesis in mice. We used the standard noise level in the animal facility as baseline and compared this condition to white noise, pup calls, and silence. In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448). All stimuli were transposed to the frequency range of C57BL/6 and hearing was objectified with acoustic evoked potentials. We found that except for white noise all stimuli, including silence, increased precursor cell proliferation (assessed 24 h after labeling with bromodeoxyuridine, BrdU). This could be explained by significant increases in BrdU-labeled Sox2-positive cells (type-1/2a). But after 7 days, only silence remained associated with increased numbers of BrdU-labeled cells. Compared to controls at this stage, exposure to silence had generated significantly increased numbers of BrdU/NeuN-labeled neurons. Our results indicate that the unnatural absence of auditory input as well as spectrotemporally rich albeit ethological irrelevant stimuli activate precursor cells-in the case of silence also leading to greater numbers of newborn immature neurons-whereas ambient and unstructured background auditory stimuli do not.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24292324</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>26</Day></DateCreated><DateCompleted><Year>2015</Year><Month>11</Month><Day>17</Day></DateCompleted><DateRevised><Year>2015</Year><Month>03</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1863-2661</ISSN><JournalIssue CitedMedium="Internet"><Volume>220</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Brain structure & function</Title><ISOAbbreviation>Brain Struct Funct</ISOAbbreviation></Journal><ArticleTitle>Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis.</ArticleTitle><Pagination><MedlinePgn>1221-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00429-013-0679-3</ELocationID><Abstract><AbstractText>We have previously hypothesized that the reason why physical activity increases precursor cell proliferation in adult neurogenesis is that movement serves as non-specific signal to evoke the alertness required to meet cognitive demands. Thereby a pool of immature neurons is generated that are potentially recruitable by subsequent cognitive stimuli. Along these lines, we here tested whether auditory stimuli might exert a similar non-specific effect on adult neurogenesis in mice. We used the standard noise level in the animal facility as baseline and compared this condition to white noise, pup calls, and silence. In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448). All stimuli were transposed to the frequency range of C57BL/6 and hearing was objectified with acoustic evoked potentials. We found that except for white noise all stimuli, including silence, increased precursor cell proliferation (assessed 24 h after labeling with bromodeoxyuridine, BrdU). This could be explained by significant increases in BrdU-labeled Sox2-positive cells (type-1/2a). But after 7 days, only silence remained associated with increased numbers of BrdU-labeled cells. Compared to controls at this stage, exposure to silence had generated significantly increased numbers of BrdU/NeuN-labeled neurons. Our results indicate that the unnatural absence of auditory input as well as spectrotemporally rich albeit ethological irrelevant stimuli activate precursor cells-in the case of silence also leading to greater numbers of newborn immature neurons-whereas ambient and unstructured background auditory stimuli do not.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kirste</LastName><ForeName>Imke</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicola</LastName><ForeName>Zeina</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Kronenberg</LastName><ForeName>Golo</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>Tara L</ForeName><Initials>TL</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Robert C</ForeName><Initials>RC</Initials></Author><Author ValidYN="Y"><LastName>Kempermann</LastName><ForeName>Gerd</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DC008343</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DC008343</GrantID><Acronym>DC</Acronym><Agency>NIDCD NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Brain Struct Funct</MedlineTA><NlmUniqueID>101282001</NlmUniqueID><ISSNLinking>1863-2653</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D055748">SOXB1 Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C527783">Sox2 protein, mouse</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Brain. 2000 Aug;123 ( Pt 8):1589-601</RefSource><PMID Version="1">10908189</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2012 Oct;13(10):727-36</RefSource><PMID Version="1">22948073</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J R Soc Med. 2001 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Plasticity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009622">Noise</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055748">SOXB1 Transcription Factors</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014828">Vocalization, Animal</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS608183</OtherID><OtherID Source="NLM">PMC4087081</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>7</Month><Day>9</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>11</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>12</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s00429-013-0679-3</ArticleId><ArticleId IdType="pubmed">24292324</ArticleId><ArticleId IdType="pmc">PMC4087081</ArticleId><ArticleId IdType="mid">NIHMS608183</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>District de Dresde</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li></settlement></list><tree><noCountry><name sortKey="Kempermann, Gerd" sort="Kempermann, Gerd" uniqKey="Kempermann G" first="Gerd" last="Kempermann">Gerd Kempermann</name><name sortKey="Kronenberg, Golo" sort="Kronenberg, Golo" uniqKey="Kronenberg G" first="Golo" last="Kronenberg">Golo Kronenberg</name><name sortKey="Liu, Robert C" sort="Liu, Robert C" uniqKey="Liu R" first="Robert C" last="Liu">Robert C. Liu</name><name sortKey="Nicola, Zeina" sort="Nicola, Zeina" uniqKey="Nicola Z" first="Zeina" last="Nicola">Zeina Nicola</name><name sortKey="Walker, Tara L" sort="Walker, Tara L" uniqKey="Walker T" first="Tara L" last="Walker">Tara L. Walker</name></noCountry><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Kirste, Imke" sort="Kirste, Imke" uniqKey="Kirste I" first="Imke" last="Kirste">Imke Kirste</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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